WELCH, DENNIE S.,AKRITOPOULOU-ZANZE, IRINI,BRAJE, WILFRIED,DJURIC, STEVAN W.,WILSON, NOEL S.,TURNER, SEAN C.,KRUGER, ALBERT W.,RELO, ANA-LUCIA,SHEKAR, SHASHANK,ZHAO, HONGYU,GANDARILLA, JORGE,GASIECKI,
申请号：
ES13161013
公开号：
ES2535490T3
申请日:
2010.05.20
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A process for preparing a compound of formula (1-5): ** Formula ** or a pharmaceutically acceptable salt thereof, where A is selected from the group consisting of ** Formula ** X1 is N or CR9； X2 is N or CR10； X3 is N or CR11； X4 is N or CR12； with the proviso that only one or two of X1, X2, X3, or X4 can be N； R9, R10, R11, R12, R13, R14, R15 and R16 each is independently hydrogen, alkyl, alkenyl, alkynyl, halogen, cyano, -G1, -G2, -NO2, -OR1a, -OC (O) R1a, -OC (O) N (Rb) (R3a), -SR1a, -S (O) R2a, -S (O) 2R2a, - S (O) 2N (Rb) (R3a), -C (O) R1a, -C (O) G3, -C (O) OR1a, -C (O) N (Rb) (R3a), -N (Rb) (R3a), -N (RaC (O) R1a, -N (Ra) C (O) O (R1a), - N (Ra) C (O) N (Rb) (R3a), -N (Ra) S (O) 2 (R2a), - (CR4aR5a) m-NO2- (CR4aR5a ) m-OR1a, - (CR4aR5a) m-OC (O) R1a, - (CR4aR5a) m- OC (O) N (Rb) (R3a), - (CR4aR5a) m-SR1a, - (CR4aR5a) mS (O ) R2a, - (CR4aR5a) mS (O) 2R2a, - (CR4R5a) S (O) 2N (Rb) (R3a), - (CR4aR5a) m (O) R1a, - (CR4aR5a) mC (O) OR1a, - (CR4aR5a) mC (O) N (Rb) (R3a), - (CR4aR5a) mN (Rb) (R3a), - (CR4aR5a) m- N (Ra) C (O) R1a, - (CR4aR5a) mN (Ra ) C (O) O (R1a), - (CR4aR5a) mN (Ra) C (O) N (Rb) (R3a), - (CR4aR5a) m-G1, -CR4a>； = CR5a-G1, - (CR4aR5a) m-G2, -CR4a>； = CR5a-G2, -CR6a-C (R7a) 2, cyanoalkyl, haloalkyl, (v), (vi), (vii) or (viii)； where ** Formula ** R1a and R3a , in each case, each is independently hydrogen, alkyl, haloalkyl G1, - (CR4aR5a) m-G1, G2, or - (CR4aR5a) m-G2； R2a, in each case, is independently alkyl, haloalkyl, G1, or - (CR4aR5a) m-G1； R6a is alkyl or haloalkyl； R7a in each case, is independently hydrogen, alkyl, or haloalkyl； R4a and R5a, in each case, each is independently hydrogen, halogen, alkyl, or haloalkyl； G1, in each case, is independently aryl or heteroaryl, where each G1 is independently unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, - NO2, -OR1b, -OC (O) R1b, -OC (O) N (Rb) (R3b), -SR1b, -S (O) R2b, -S (O) 2R2b, - S (O) 2N (Rb )
