Analyzing Immune Signaling Networks for Identification of Therapeutic Targets in Complex Chronic Medical Disorders, Identification of a Natural Killer Cell Population as a Potential Therapeutic Target for Gulf War Illness And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, And Modulation of Natural Killer Cell Function by Stimulation with Interleukin 15
Mary Ann FLETCHER,Gordan BRODERICK,Nancy KLIMAS,Zachary BARNES
申请号：
US15028757
公开号：
US20160275236A1
申请日:
2014.10.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).
