The present invention includes novel methods of treating a disease or disorder characterized by hyperactivity of Vps34, and compound as Vps34 inhibitors； particularly compounds of Formula I or a pharmaceutically acceptable salt thereof, as well as methods of treating a disease, disorder, or syndrome associated with Vps34 inhibition, particularly hyperproliferative diseases. The present invention also includes pharmaceutical compositions including compounds of formula I and pharmaceutically acceptable salts thereof.本発明は、Ｖｐｓ３４の機能亢進を特徴とする疾患または障害の新しい処置方法、および、Ｖｐｓ３４阻害剤としての化合物；特に式Ｉの化合物またはその薬学的に許容される塩、並びに、Ｖｐｓ３４阻害に関連する疾患、障害または症候群、特に過増殖性疾患の処置方法を含む。本発明は、また、式Ｉの化合物およびその薬学的に許容される塩を含む医薬組成物を含む。
