The present invention relates to a novel method for preparing induced pluripotent stem cells (iPSCs) by introducing four genes, Oct-4, Sox2, Klf4, and Glial, into somatic cells. The present invention also relates to the iPSCs produced by the aforementioned method. Also provided is a process of drug selection for a heritable genetic disease by use of the iPSCs produced by the aforementioned method. In particular, wherein the inherited disease is Fabry disease. The present invention also relates to a method for treating Fabry-associated myocardiopathy in a subject in need thereof, and a method for determining prognosis in a subject with Fabry-associated myocardiopathy.本發明涉及一種新穎的製備誘導性多功能幹細胞(induced pluripotent stem cells,iPSCs)之方法,透過將Oct-4、Sox2、Klf4以及Glial這四個基因導入體細胞中來達成。本發明還涉及透過上述方法製備的誘導性多功能幹細胞(iPSCs)。亦提供一種針對遺傳性疾病的藥物篩選方法,透過使用由上述方法製備的iPSCs來達成。具體而言,其中該遺傳性疾病為法布里氏病(Fabry disease)。本發明還涉及一種於需要之個體治療與法布里氏病相關的心肌病之方法,以及一種用於判斷罹患法布里氏病相關的心肌病之個體的預後的方法。
