The USA; as represented by the Secretary; Department of Health and Human Services
发明人:
Peter L. COLLINS,Ursula J. BUCHHOLZ
申请号：
US15773653
公开号：
US20180318411A1
申请日:
2016.11.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Respiratory syncytial virus (RSV) infection may lead to severe respiratory illness in young children. Thus, there is a need for a live attenuated vaccine, which would mimic the natural course of infection without causing illness； however, restricting viral replication also reduces the immune response. Reported herein is a method of vaccination using a single dose of a recombinant RSV lacking the M2-2 protein that surprisingly induced a stronger immune response to RSV than previous vaccine candidates despite being more restricted in replication.
