Behnam BADIE,Leying ZHANG,Darya ALIZADEH,Dongchang ZHAO,Jacob BERLIN
申请号：
US13673973
公开号：
US20130210896A1
申请日:
2012.11.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
One aspect of the invention relates to a nanoparticle conjugated CpG (NANO-CpG) composition and pharmaceutical composition thereof, and the preparation methods thereof. Another aspect of the invention relates to a method for using the NANO-CpG to improve CpG delivery into brain tumor associated inflammatory cells in a subject. Another aspect of the invention relates to a method for treating or preventing a method for treating and/or preventing a brain tumor in a subject comprising administering a therapeutically effective amount of the NANO-CpG or a pharmaceutical composition thereof to the subject. In one embodiment, a subject treated with the NANO-CpG composition disclosed herein or a pharmaceutical composition thereof developed immunity to brain tumor.
