The present disclosure includes methods and compositions for the treatmentor prevention of diseases and disorders characterized by excessive or misregulatedcellular proliferations, including methods for the treatment of tumors. Themethods involve the use of pharmaceutical compositions comprising at leastone agent selected from the group consisting of a LIF preparation, a BMP preparation,a BMPR signalling activator, and a LIFR signalling activator. The disclosurealso includes LIF preparations, BMP preparations, BMPR signalling activator,and LIFR signalling activators, and methods for the identification of LIF preparations,BMP preparations, BMPR signalling activator, and LIFR signalling activators.The disclosure also includes pharmaceutical compositions comprising at leastone agent selected from the group consisting of a LIF preparation, a BMP preparation,a BMPR signalling activator, and a LIFR signalling activator.
