ARNAB CHATTERJEE,ADVAIT NAGLE,PRASUNA PARASELLI,RAVINDER REDDY KONDREDDI,SEH YONG LEONG,PRANAB MISHRA,ROBERT MOREAU,JASON THOMAS ROLAND,WEI LIN SANDRA SIM,SIMON OLIVER,LIYING JOCELYN TAN,BRYAN KS YEUN
申请号：
ARP130104250
公开号：
AR093532A1
申请日:
2013.11.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
In addition, pharmaceutical ingredients containing such compounds are provided, as well as the pathology and / or symptoms of using such compounds to treat, prevent, suppress, improve or eradicate diseases caused by parasites such as malaria. 1. Claim 1: a formula compound (1),o. Or a pharmaceutically acceptable salt, tautometer or stereoisomer, n is 0, 1, 2 or 3； P is 0, 1, 2 or 3； L from * - (CHr) 83218331 -；-CHR N (R) --Nitrous oxide* - three -*-(o) -,-CHR N (R) CHR -*C (o)..-C (O) N (R) --C (O) N (R) CHR -*N (R2)..-N (R) CHR --N (R) C (O) --N (R) C (O) N (R) --N (R) S (O) -a. * represents the polymerization point (1) of pirazolo [1, 5-a] piridine from L to fusion ring as shown in the formula；each R² is independently selected from the group consisting of hydrogen, C₁₋₆-alkyl,halo-alkyl Cilo,R-alkylene C₀₋₄,and R-Cquile-C (O) alkylene -,where R is selected from the group consisting of hydroxyl, C₁₋₄ alkoxy,amino alquil C amino cicloalquilo CC₄₋₆ heterocycloalkyl,And abnormity c83318326；where the cycloalkyl C₃₋₆,C₄₋₆ heterocycloalkyl,and C₅₋₆ heteroaryl of R are each substituted or unsubstituted by 1-2 substituents independently selected from the group consisting of halo, amino, hydroxyl, C₁₋₄ alkyl,C₁₋₄ alkoxy,oxo, and C₅₋₆ heteroaryl；and each R³ is independently selected from the group consisting of hydrogen and C₁₋₄-alkyl；ring A is selected from the group consisting of C₆₋₁₀ aryl and C₅₋₁₀ heteroaryl；ring C is selected from the group consisting of C₆₋₁₀ aryl,C₅₋₁₀ heteroaryl,cycloalkyl C₅₋₇,3. Direct loop electrolysisand fused bicyclyl comprising a phenyl-fused C₅₋₆ heterocycloalkyl； each R¹ is independently selected from the group consisting of halo, cyano, amino, C₁₋₄ alkyl,C₁₋₄ alkoxy,halo-alkyl Cilo,-C (o) No. 8311； (r83212)；-NHC (O) Rphenyl, and C₅₋₆ heteroaryl；wherein the phenyl and C₅₋₆ heteroaryl of R¹ are each substituted or unsubstituted by 1-2 substituents independently selected from the group consisting of C₁₋₄ alkyl,amino, halo, and alkyl C₁₋₄amino；
