The invention generally relates to the transdermal delivery of multiple compositions. In certain respects, the transdermal delivery can be promoted by utilizing an adverse biophysics environment. One set of embodiments of the invention provides a surface delivery composition containing ibuprofen and/or ibuprofen salts, a nitric oxide donor and an optionally selected adverse biophysics environment. In some situations, the composition can be stabilized by using stabilized polymers (such as xanthan gum, BT and/or RD, propylene glycol and a polysorbate surfactant such as polysorbate 20). Compared with the composition lack of one or more than one stabilized polymer, the temperature stability of the composition provided by the invention is unexpectedly realized by virtue of the stabilized polymers, for example: the temperature stability of the composition at a rising temperature (such as at least 40 DEG C (at least about 104 DEG F)) is ensured.
