Alan D. DAndrea,Patrizia Vinciguerra,Stephen J. Elledge,Shuhei Matsuoka,Agata M. Smogorzewska,Kay O. Hofmann
申请号：
US13413129
公开号：
US20130280258A1
申请日:
2012.03.06
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention identifies and characterizes the FANCI polypeptide as a vital component of the Fanconi anemia pathway and discloses inhibitors of FANCI and methods of using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.
