Anti-tyrosinase-realted protein-1 (TYRP1) antibodies

• 收藏
• 分享

专利权人:

IMCLONE LLC

发明人:

KANG, XIAOQIANG,BALDERES, PAUL J

申请号：

NZ58730509

公开号：

NZ587305A

申请日:

2009.03.11

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

A monoclonal antibody that specifically binds to human TYRP1 (SEQ ID NO. 28) and comprises a VH chain with the amino acid sequence: QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLDYWGQGTLVTVSS (SEQ ID NO: 14), a CDRL1 having the sequence RASQSVSSYLA (SEQ ID NO: 4), a CDRL2 having the sequence DASNRAT (SEQ ID NO: 5), and a CDRL3 having the sequence QQRSNWLMYT (SEQ ID NO: 6). The antibody can be used to treat malignant melanoma.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/