SUPPORTS DE MÉDICAMENTS POLYMÈRES DENDRITIQUES DE POIDS MOLÉCULAIRE ÉLEVÉ ET LEURS CONJUGUÉS AVEC DES MÉDICAMENTS, NOTAMMENT POUR LE TRAITEMENT DE TUMEURS SOLIDES
USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.;MIKROBIOLOGICKY USTAV AV CR, V.V.I.
发明人:
申请号：
EP10812977.6
公开号：
EP2512521B1
申请日:
2010.12.14
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
