The present invention provides a controlled release particle comprising a therapeutically effective amount of acid fibroblast growth factor (aFGF), entrapped by a particle composed by a biocompatible anionic biopolymer capable of binding to aFGF, and a cationic polymer. The method for manufacturing the controlled release particle and the method of using the particle for treating nervous injury are also provided.本發明提供一種控制釋放粒子，其包含治療有效量之酸性纖維母細胞生長因子(aFGF)，包覆於粒子中，該粒子由可結合至aFGF之生物相容性陰離子生物聚合物所構成，及一陽離子聚合物。亦提供製造該控制釋放粒子之方法及使用該粒子來治療神經損傷之方法。
