The present invention discloses a method of treating agitation or the signs of agitation in a subject comprising the sublingual administration of an effective amount of an alpha-2 adrenergic agonist, more particularly Dexmedetomidine, or a pharmaceutically acceptable salt thereof. The method is particularly suitable for the treatment of agitation associated with neurodegenerative and/or neuropsychiatric diseases. The present invention also discloses the sublingual administration of an alpha-2 adrenergic agonist, more particularly Dexmedetomidine or a pharmaceutically acceptable salt thereof at a dose that is effective to treat agitation or the signs of agitation in a subject, but does not cause significant sedation.本發明揭示一種治療個體之激躁或激躁病徵之方法，其包含舌下投與有效量之α-2腎上腺素促效劑，更尤其迪美得托咪汀或其醫藥學上可接受之鹽。該方法尤其適用於治療與神經退化性及/或神經精神疾病相關之激躁。本發明亦揭示以有效地治療個體之激躁或激躁病徵，但不導致顯著鎮靜之劑量舌下投與α-2腎上腺素促效劑，更尤其迪美得托咪汀或其醫藥學上可接受之鹽。
