COMPOSES [3-HETEROARYL-2-TRIFLUOROMETHYL-PROPYL]-PIPERIDIN-1-YLE OU -MORPHOLINE-4-YLE EN TANT QU'ANTAGONISTES DE TRPA1 POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

BROTHERTON-PLEISS, CHRISTINE E.,ERICKSON, SHAWN DAVID,LI, HONGJU,SO, SUNG-SAU

申请号：

CA2884433

公开号：

CA2884433A1

申请日:

2013.11.06

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

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