MCDONALD, Ivar M.,ZUSI, F. Christopher,OLSON, Richard E.
申请号：
ES15729057
公开号：
ES2666794T3
申请日:
2015.06.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I ** Formula ** where: Ar1 is selected from the group consisting of phenyl, pyrrolyl, furanyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, naphthalenyl, indolyl, indazolyl, benzofuranyl, dihydrobenzofuranyl, benzodioxolanyl, benzothiophenyl, dihydrobenzothiophenyl, benzoisothiazolyl, benzothiazolyl, thienopyrazinyl, pyrrolopyridyloxy, substituted quinoline, isocyl, trinoxyl, and pyrolinoidyl group, substituenyl, and quinopyrinoxyl, isocyl, pyridyloxy, nyl, and pyrolinoidyl, n-yol group, substituted with 0-ylino-pyridyloxy, n-yol, and pyrolyloxy, nyl, and pyrolinoxylazoyl, n-substituted group, and, in the same way it consists of cyano, halo, alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, alkylthio and Ar2； Ar2 is phenyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy and haloalkoxy； and a is 0, b is 1, c is 0, d is 0 and e is 1； or a is 0, b is 1, c is 1, d is 0 and e is 1； or a is 1, b is 0, c is 0, d is 1 and e is 0； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula I**Fórmula** donde: Ar1 se selecciona del grupo que consiste en fenilo, pirrolilo, furanilo, tienilo, pirazolilo, isoxazolilo, isotiazolilo, imidazolilo, oxazolilo, tiazolilo, triazolilo, oxadiazolilo, tiadiazolilo, piridinilo, piridazinilo, pirimidinilo, pirazinilo, naftalenilo, indolilo, indazolilo, benzofuranilo, dihidrobenzofuranilo, benzodioxolanilo, benzotiofenilo, dihidrobenzotiofenilo, benzoisotiazolilo, benzotiazolilo, tienopirazinilo, pirrolopiridinilo, benzoisoxazolilo, quinolinilo, isoquinolinilo, quinoxalinilo y naftiridinilo, y está sustituido con 0-3 sustituyentes seleccionados del grupo que consiste en ciano, halo, alquilo, haloalquilo, cicloalquilo, alcoxi, haloalcoxi, alquiltio y Ar2； Ar2 es fenilo sustituido con 0-3 sustituyentes seleccionados de ciano, halo, alquilo, haloalquilo, alc
