One bracelet embodiment provides therapeutic blood irradiation at a first wrist region using a first module, and body temperature regulation/irradiation at a second wrist region using a second module. A connector couples one end of the modules together, while an attachment band releasably couples the second ends together, for attachment to the wrist. The first module includes first and second distributed pluralities of lights respectively emitting 850 and 660 nm wavelengths, and a third plurality emitting 630 nm, 532 nm, and 450 nm wavelengths, positioned in a row substantially parallel to the arm of the user. The second module includes first and second rows of lights on first and second sides of a cooling unit, each emitting 405 nm wavelengths, with the two rows positioned for penetration to the radial and ulnar arteries. The bracelet includes a microprocessor, LED screen, and firmware for displaying a GUI permitting treatment protocol selections.