The disclosure provides a method to administer noribogaine to a human patient having drug addiction in dosages that provide efficacy without leading to any significant deleterious clinical signs.本發明提供一種將降伊伯格鹼(noribogaine)投與具有藥物成癮之人類患者的方法,其投藥劑量可在不會造成任何顯著的有害臨床徵象下同時提供藥效。