The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases related to various disorders of cell proliferation and development. The invention also relates to methods for producing the indicated antibodies, and to a method for treating human diseases using said antibodies.
