Marion W. Anders,James L. Robotham,Shey-Shing Sheu,Paul Spencer Brookes,Jalil Shojaie,Leif Olson,Richard L. Parton
申请号：
US12694337
公开号：
US08470861B2
申请日:
2010.01.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
