A human monoclonal antibody or its antigen-binding portion that specifically binds to Mucosal Adressin Cell Adhesion Molecule (MAdCAM), is new. A human monoclonal antibody or its antigen-binding portion, produced by a hybridoma cell line, that specifically binds to Mucosal Adressin Cell Adhesion Molecule (MAdCAM), where the antibody is selected from an antibody comprising any of the 17 sequences of 233-241 amino acids (SEQ ID NOS: 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 54, 58, 62, 66 or 68), without the signal sequences, where the heavy chain of the antibody or its portion comprises the heavy chain CDR1, CDR2 and CDR3 amino acid sequences of a reference monoclonal antibody and/or where the light chain comprises the light chain CDR1, CDR2 and CDR3 amino acid sequences of a reference monoclonal antibody, where the antibody or its portion comprises one or more of an FR1, FR2, FR3 or FR4 amino acid sequence of a human monoclonal antibody, where the reference or human monoclonal antibody is selected from 1.
