The present invention provides methods and systems of using wavelet transform in a dual-track architecture to process ECG signals of patients and reference ECG signals of previously studied subjects to assess the cardiovascular health of the patients. The dual-track architecture refers to running wavelet transform on the ECG signals of the patients and the reference ECG signals to extract and analyze 2-dimensional time-domain signal characteristics of the ECG signals, and to build and analyze a 3-dimensional model of frequency-domain and time-domain information of the ECG signals. The characteristics of the ECG signals of the patients and the reference ECG signals may be compared and used to identify a cardiovascular disease of the patient or to recommend follow-up tests. The results of the comparison may also be used to configure the ECG device used to acquire the ECG signals of the patient and/or to optimize the parameters of the 2-D/3-D analysis.
