Immune, inflammatory and degenerative artfiri tides, including rheumatoid arthritis, hemophiliac arthropathy and osteoarthritis, can be treated using a systemic or intra¬ articular radi osy novectomy technique in which the radionuclide is high specific activity tin- 117m. Tin-117m can either be bound to a colloid typically used in an intra-articular radiosynovectomy (RSV), or can betin-117m annexin for RSV and systemic administration.