CHUNG, BONG YOULKR,정봉열,LIM, CHAE YOUNGKR,임채영,KIM, DOO HOKR,김두호,LEE, SIN GUKR,이신구,KIM, HYUN AKR,김현아,LEE, JONG OHKR,이종오
申请号：
KR1020140118582
公开号：
KR1020150029578A
申请日:
2014.09.05
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
Provided in the present invention are a hyaluronic acid cross-linked in a high density reticular structure, which has excellent crosslinking ratio and has optimized biological affinity and continuity and a method for preparing the same. The method for preparing hyaluronic acid cross-linked in high density reticular structure comprises the steps of (i) linearizing a hyaluronic acid polymer by dissolving in an aqueous alkali solution (ii) obtaining hydrogel by cross-linking the linearized hyaluronic acid with a cross-linking agent (iii) cutting the hydrogel (iv) swelling the cut hydrogel by using a buffer solution of pH 6.8 or less and (v) crushing the swelled hydrogel.COPYRIGHT KIPO 2015본 발명은 높은 가교율로 인해 우수한 점탄성을 가지고, 생물학적 친화성 및 지속성이 최적화된 고밀도 망상구조로 가교된 히알루론산 및 그의 제조방법을 제공한다.
