According to some embodiments, the present invention provides a modified silicone surface for interference to pathogen colonization comprising: an activated silicone layer a plurality of cross-linking dendrimers adsorbed onto to the activated silicone layer a plurality of ligand derivatives, each bound to at least one of the plurality of cross-linking dendrimers and a benign biofilm adhered to the plurality of ligand derivatives. According to some embodiments, the present invention provides a method for making a modified silicone surface for interference to pathogen colonization comprising activating a silicone surface adsorbing a plurality of cross-linking dendrimers to the silicone surface binding a plurality of ligand derivatives to the plurality of cross-linking dendrimers and adhering a benign biofilm to the plurality of ligand derivatives.
