An automatic unattended-monitoring visual acuity inspection device is disclosed. The inspection device includes an inspection panel, an inspector (2) and an isolation wall (3) arranged opposite to the inspection panel. The inspection panel includes a liquid crystal display panel (12), a lower polarizer (13) and a backlight source (14). The liquid crystal display panel (12) is configured to display visual display pictures. The isolation wall (3) is provided with a wireless signal transmitter configured to transmit a visual acuity indication signal collected from a person to be inspected to the wireless signal receiver through a network. The wireless signal receiver is configured to transmit the received visual acuity indication signal to a processor. The processor is configured to process the visual acuity indication signal and transmit a process feedback to the inspection panel. The device may prevent achieving a high level of visual acuity of the person to be inspected by cheating behaviors, such as remembering position information regarding an inspection chart or reminding the person to be inspected by other persons, thereby highly inspecting a real visual acuity level of the person to be inspected. The device is suitable for applying in those occasions where a strict requirement for visual acuity inspection is needed.