The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.本發明專利提供以高親和力特異性結合CD22的分離的單株抗體,特別是人類單株抗體。編碼本揭露專利的該抗體的核酸分子和表達本揭露專利的該抗體的表達載體、宿主細胞、方法也被提供了。含本揭露專利的該抗體的抗體－相對配對分子共軛物、雙特異性分子和藥物組合物也被提供了。本揭露專利也提供檢測CD22的方法,以及治療用本揭露專利的抗－CD22抗體治療各種癌症和炎症及自體免疫的方法。
