Government of the United States as Represented by the Secretary of the Air Force
发明人:
Thomas J Lamkin,Roland Saldanha
申请号：
US14480071
公开号：
US20160067323A1
申请日:
2014.09.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention includes live strain of Francisella tularensis wherein a gene selected from the group consisting of priA and purA is inactivated. The present invention further includes a pharmaceutical composition comprising one or more live strains of Francisella tularensis according to the present invention and a pharmaceutically acceptable carrier. The present invention further includes a method of using one or more live strains of Francisella tularensis according to the present invention to confer immunity against a virulent strain of Francisella tularensis. The method comprises administering an effective amount of one or more live strains of Francisella tularensis according to the present invention or a pharmaceutical composition comprising one or more live Francisella tularensis strains to an animal such that an immune response is produced in the animal.
