Hye Yeong NAM,Sang-Hee KIM,Min-Hyo SEO,Ji-Yeon SON
申请号：
US15781182
公开号：
US20180344638A1
申请日:
2016.12.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed is a method for preparing a composition for an anionic drug delivery with increased production yield, comprising forming nanoparticles by using electrostatic interaction of an anionic drug and a cationic compound in an aqueous phase； and incorporating the nanoparticles into polymeric micelles comprising an amphiphilic polymer and optionally a polylactic acid salt to increase the electrostatic interaction and hydrophobic binding, thereby increasing the entrapment efficiency of the anionic drug in the formulation.
