Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells

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专利权人:

Elfriede Noessner;Christine Falk;Dolores Schendel;Elisabeth Weiss

发明人:

Elfriede Noessner,Elisabeth Weiss,Dolores Schendel,Christine Falk

申请号：

US12765234

公开号：

US08142772B2

申请日:

2010.04.22

申请国别(地区):

US

年份:

2012

代理人:

摘要：

This invention is directed to therapeutic compositions containing non-MHC-restricted Tcells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which comprise LAK cells. Furthermore, the present invention is directed to the use of the above combination in the treatment of tumors in humans, which tumors show a missing, low or aberrant expression of MHC class Ia or Ib molecules. By using the aforementioned compositions/combinations it is possible to provide a balanced selective pressure against emergence of tumor cell variants that would otherwise escape immune detection.

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中国工程科技知识中心

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http://www.ckcest.cn/home/