КАРРИ Марк Дж. (US),ЗИММЕР Дэниел П. (US),ФРЕТЦЕН Ангелика (US),КЕССЛЕР Марко (US),КАЛИ Брайан М. (US)
申请号：
RU2012128509/04
公开号：
RU2012128509A
申请日:
2010.12.07
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The peptide or its pharmaceutically acceptable salt, where the peptide contains the amino acid sequence HaaXaaXaaXaaCysXaaXaaXaaCysAsnProAlaCysXaaGlyXaaXaa, (SEQ ID NO: 1) or a pharmaceutically acceptable salt thereof； wherein Xaa is Asn, D-Asn, Gln, D-Gln, Pro, D-Pro, Ala, β-Ala, D-Ala, Val, D-Val, Gly, Thr, D-Thr, Asp, D-Asp, β-carboxylated Asp, Glu, D-Glu, γ-carboxylated Glu, α-aminosuberic acid (Asu), α-aminoadipic acid (Aad) or α-aminopimelic acid (Apm)； Asp, β-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm or absent； Asp, β-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm or absent； Xaa is Cys or D-Cys； Xaa is Asp or Glu； Xaa is Tyr , Leu, Phe or Ile； Xaa is Cys or D-Cys； Thr, Ala or Phe is Xaa； Xaa is Cys or D-Cys； and Xaa is Tyr, D-Tyr or absent； in this case, the amino group Xaa can be modified with methyl, oxalic acid, propanedioic acid, ethanedicarboxylic acid, glutaric acid, hexanedioic acid, pimelic acid or suberic acid； if Haai Haa is absent, Xaa must be β-carboxylated Asp or γ-carboxylated Glu or Xaa must be Asp, D-Asp, Glu, D-Glu, Asu, Aad, Apm at its amino group must be modified with oxalic acid, propanedioic acid or ethanedicarboxylic acid, glutaric acid, hexanedioic acid, pimelic acid or suberic acid. 2. The peptide or a pharmaceutically acceptable salt thereof according to claim 1, wherein Asp or Glu is present； both are present； both Asp or Glu are present； are present and are absent； or Haai Haa both present. 3. The peptide or its pharmaceutically acceptable salt according to claim 1, where one or both of Haai Haa are present, and Xaa is A1. Пептид либо его фармацевтически приемлемая соль, где пептид содержит последовательность аминокислотХааХааХааХааCysXaaXaaXaaCysAsnProAlaCysXaaGlyXaaXaa, (SEQ ID NO:1) либо его фармацевтически приемлемую соль； при этомXaaявляется Asn, D-Asn, Gln, D-Gln, Pro, D-Pro, Ala, β-Ala, D-Ala, Val, D-Val, Gly, Thr, D-Thr, Asp, D-Asp, β-карбоксилированной Asp, Glu, D-Glu, γ-карбоксилированной Glu, α
