Ambrish Kumar,Ugra Sen Singh,Daping Fan,Donald J. Dipette
申请号：
US14483445
公开号：
US09446019B2
申请日:
2014.09.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Use of sparstolonin B in inhibition of growth and/or viability of human neuroblastoma cells is described. The sparstolonin B can be naturally derived from the Chinese herb Sparganium stoloniferum or can be synthetic. The sparstolonin B is shown to be effective both in vitro and in vivo in inhibition of growth and/or viability of neuroblastoma cells of multiple different genetic backgrounds including N-myc amplified with wild p53 neuroblastoma cells, N-myc amplified with mutated p53 neuroblastoma cells, and N-myc nonamplified neuroblastoma cells.
