Institut National de la Sante et de la Recherche Medicale
发明人:
Michel Pierres,Eric Vivier,Myriam Baratin
申请号：
US14450921
公开号：
US09663577B2
申请日:
2014.08.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are monoclonal antibodies that specifically bind to the B7 family member B7H6, including antibodies capable of inhibiting the interaction of B7H6 with NKp30. Also disclosed are anti-B7H6 antibody-drug conjugates comprising an anti-B7H6 monoclonal antibody conjugated to a therapeutic agent. The anti-B7H6 antibodies and antibody-drug conjugates are useful in methods for exerting therapeutic effects against B7H6-expressing cells, as well as in diagnostic methods for the detection of B7H6 or B7H6-expressing cells.
