PROBLEM TO BE SOLVED: To provide a pharmaceutical composition or the like which is useful for treatment and prevention of neurodegenerative disease, particularly prevention and treatment of disease caused by the formation of intracellular aggregates of TDP-43.SOLUTION: A pharmaceutical composition for treatment and/or prevention of neurodegenerative disease comprises retinoic acid, or its prodrug, or their pharmacologically acceptable salts, or their hydrates or solvates, as an active ingredient.COPYRIGHT: (C)2015,JPO&INPIT【課題】神経変性疾患の治療及び予防、特にTDP-43の細胞内凝集体の形成に伴う疾患の予防及び治療に有用な医薬組成物等を提供する。【解決手段】本発明に係る神経変性疾患の治療及び/又は予防用医薬組成物は、レチノイン酸、若しくはそのプロドラッグ、又はそれらの薬理学的に許容し得る塩、あるいはそれらの水和物若しくは溶媒和物を有効成分として含むものである。【選択図】なし
