This invention relates to technique for improving dermic environment and delivering active ingredients of protecting agent to dermis. The vesicle comprises (1) α, ε -bis(γ -N-(C10~30)acylglutamyl)lysine and/or slat thereof, (2) ceramide and/or derivatives thereof, and (3) more than 1 or 2 of glycerin fatty ester, poly glycerin fatty ester or pyroglutamic acid glycerin fatty ester. It is preferred that the acyl of α, ε -bis(γ -N-(C10~30)acylglutamyl)lysine is lauroyl and the ceramide and/or derivatives thereof are ceramide type 2 or ceramide type 3. The vesicle may include active ingredients and be contained in skin external-use agents.本發明係提供一種改善真皮環境或使作為保全劑的有效成分可到達真皮之技術。一種囊胞(vesicle)，其係含有1)α,ε-雙(γ-N-(碳數10~30)醯基麩胺醯基)離胺酸及/或其鹽、2)神經醯胺及/或其衍生物、和3)選自脂肪酸甘油酯、聚脂肪酸甘油酯及焦麩胺酸脂肪酸甘油酯中的1種或2種以上。上述α,ε-雙(γ-N-(碳數10~30)醯基麩胺醯基)離胺酸中的醯基，宜為月桂醯，上述神經醯胺及/或其衍生物，宜為神經醯胺-類型2或神經醯胺-類型3。囊胞係可內含有效成分。使囊胞含於皮膚外用劑。
