Tricyclic pyrido-carboxamide derivatives as ROCK inhibitors

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专利权人:

Bristol-Myers Squibb Company

发明人:

QUAN, Mimi L.,HU, Zilun,WANG, Cailan,PATIL, Sharanabasappa

申请号：

ES14741757

公开号：

ES2633987T3

申请日:

2014.07.01

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound according to formula (I): ** (See formula) ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein A1 and A2 are CR1； A3 is independently selected from N and CR1； B is independently selected from -O-, -CR3R4O-, -OCR3R4-, -NRa-, -C (O) O-, -OC (O) -, -C (O) NRa-, -NRaC (O) - and -S-； L is independently selected from - (CR6R7) q, - (CR6R7) sNR5 (CR6R7) q-, - (CR6R7) sO (CR6R7) q- and - (CR6R7) sC (O) (CR6R7) q-； R1 is independently selected from H, F, Cl, Br, CN, NRaRa, -C1-4 alkyl substituted with 0-3 Re, C1-4 alkyl substituted with 0-3 Re, - (CH2) rORb, - (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC (>； = O) N RaRa, - (CH2) rC (>； = O) (CH2) rNRaRa, - (CH2) rCN, - (CH2) rNRaC (>； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC ( >； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O) pNRaRa, - (CH2) rNRaS (O) pRc, (CH2) ) C3-6 r-carbocyclyl substituted with 0-3 Re and - (CH2) r-heterocyclyl substituted with 0-3 Re； R2 is independently selected from H, F, Cl, Br, CN, NRaRa, -C1-4 alkyl substituted with 0-3 Re, C1-4 alkyl substituted with 0-3 Re and - (CH2) rORb； R3 and R4 are independently selected from H, F, OH, CN, NRaRa, C1-4 alkyl substituted with 0-3 Re, C1-4 alkenyl substituted with 0-3 Re and C1-4 alkynyl substituted with 0-3 Re, - (CH2) rORb, (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC>； = O) NRaRa, - (CH2) rC ( >； = O) (CH2) rNRaRa, (CH2) rCN, - (CH2) rNRaC (>； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O) p NRaRa, - (CH2) rNRaS (O) pRc, (CH2) C3-6 r-carbocyclyl substituted with 0-3 Re, and - (CH2) r-heterocyclyl substituted with 0-3 Re； R5 is independently selected from H and C1-4 alkyl optionally substituted with F, Cl, Br, CN, -ORb, -S (O) pRc, -C (>； = O) Rb, -NRaR

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