Oxazole and thiazole Compounds, Selective inhibitors of Protein Kinases； Pharmaceutical composition, Pharmaceutical Combination； its use in the treatment of diseases such as mastocytosis, haematological neoplasm, myeloproliferative disorder disease, autoimmune disease, flammable Atoria, allergies or Neurological disease.
MOUSSY ALAIN,MARTIN JASON,PEZ DIDIER,SANDRINELLI FRANCK,BENJAHAD ABDELAH,CHEVENIER EMMANUEL,PICOUL WILLY,LERMET ANNE
申请号：
CL2014000007
公开号：
CL2014000007A1
申请日:
2014.01.03
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.COMPUESTOS DERIVADOS DE 2-(FENILAMINO)-(OXAZOL O TIAZOL) SUSTITUIDOS, INHIBIDORES SELECTIVOS DE LA PROTEINA QUINASA, PARTICULARMENTE A TIROSINA QUINASA； COMPOSICIÓN FARMACÉUTICA； ÚTILES PARA EL TRATAMIENTO DE LA MASTOCITOSIS, NEOPLASIA HEMATOLOGICA, TRASTORNO MIELOPROLIFERATIVO, ENFERMEDAD AUTOINMUNE E INFLAMATORIA, ALERGIAS O ENFERMEDAD NEUROLOGICA, ENTRE OTRAS.
