A series of substituted arylsulfone derivatives represented by Formula I or their pharmaceuticalAcceptable salts for. The pharmaceutical composition comprises an effective amount of a compound of the present invention alone or in combination with one or more otherIn combination with a therapeutically active compound and a pharmaceutically acceptable carrier. For example,Sexual pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, urinary incontinence, pruritus, allergic skinFlames, epilepsy, diabetic neuropathy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, sleepIt involves calcium channel activity, including disorders, bipolar disorder and stroke, or itA method of treating a condition caused by an effective amount of a compound of the present invention alone or in combination with one or moreIn combination with other therapeutically active compounds.式Iによって表される一連の置換アリールスルホン誘導体またはそれらの医薬的に許容し得る塩。医薬組成物は有効量の本発明の化合物を単独で、または1種類以上の他の治療上活性の化合物および医薬的に許容し得る担体との組み合わせで含む。例えば、急性痛、慢性痛、内臓痛、炎症性疼痛、神経障害性疼痛、尿失禁、掻痒、アレルギー性皮膚炎、てんかん、糖尿病性神経障害、過敏性腸症候群、うつ病、不安、多発性硬化症、睡眠障害、双極性障害および発作を含む、カルシウムチャネル活性に関与するか、またはそれによって生じる状態の治療方法は、有効量の本発明の化合物を単独で、または1種類以上の他の治療上活性の化合物との組み合わせで投与することを含む。
