GADHACHANDA VENKAT RAO,WANG QIUPING,PAIS GODWIN,HASHIMOTO AKIHIRO,CHEN DAWEI,WANG XIANGZHU,AGARWAL ATUL,DESHPANDE MILIND,WILES JASON ALLAN,PHADKE AVINASH S
申请号：
AP201609434
公开号：
AP201609434A0
申请日:
2015.02.25
申请国别(地区):
AP
年份:
2016
代理人:
摘要：
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula II, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.
