The present invention relates to a cartridge for a drug delivery device, comprising a barrel (52； 62； 72； 82； 92) of substantially cylindrical shape and at least one piston arrangement (54； 64； 74； 84, 85； 94, 95, 97) displaceably arranged in the barrel, wherein the piston arrangement (54； 64； 74； 84, 85； 94, 95, 97) occupies at least 20% of the volume confined by the barrel (52； 62； 72； 82； 92).
