#$%^&*AU2015200991A120150917.pdf#####49 ABSTRACT A method of treating a disease, disorder or condition of the eye includes irradiating the eye or eyes with a laser and subsequently detecting one or 5 more biological responses by the eye or eyes to thereby determine the effectiveness of the laser treatment. The one or more biological responses by the eye or eyes are responses by cells, tissues and/or molecules of the eye or eyes that indicate, are associated with, or are functionally linked to, the effectiveness of the laser treatment. This may include detecting or 10 measuring a change in the expression of one or more genes after laser treatment, such as cytoskeletal genes, matrix metalloproteinase genes, cell cycle genes and extracellular matrix genes. The method may include detecting or measuring cell differentiation, cell death and/or cell proliferation after laser treatment. 156/8 Aft -~1000(3 4. 9001800- I rn E - 700- 2 6005 500m 00t ~ l i t G _ mControl eye M Control eye 1.- M Lasered eye 2.- M Lasered eye n- = Fellow eye 1=1 Felloweye (OwD ~a 1.0-.C 0.0 o3- -10. -QC711 ApoEnull 8C57B16 ApoEnull FIG. 6
