Caetano Reis E Sousa;Olivier Pierre Joffre;Oliver Schulz;David Sancho-Madrid;Daniel Pennington;Neil Charles Rogers
发明人:
David Sancho-Madrid,Oliver Schulz,Neil Charles Rogers,Caetano Reis E Sousa,Olivier Pierre Joffre,Daniel Pennington
申请号：
US12669940
公开号：
US08580266B2
申请日:
2008.07.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.
