An architecture is presented that provides a topical cream delivery device designed for effectively and easily administering hydrating and pain-relieving creams to dialysis patients' and other “in need” patients' needle sites. The topical cream delivery device comprises an adhesive bandage strip and a cavity positioned along the adhesive bandage strip. The cavity is typically filled with a hydrating and pain-relieving cream for dialysis patients, but could be filled with any other suitable cream or drug as well. The adhesive bandage strip further comprises an adhesive backing, for adhering to a user's skin. The adhesive bandage strip is attached to the adhesive backing on one side and covered with a protective paper on the other and cut to shape for application to a body surface. A user when using the topical cream delivery device peels off the protective paper from the adhesive backing and adheres the device to a body surface.