您的位置: 首页 > 农业专利 > 详情页

Novel inducible animal models of stress behavior
专利权人:
发明人:
申请号:
EP12195863.1
公开号:
EP2740353A1
申请日:
2012.12.06
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to a method of producing an inducible animal model of stress comprising genetically modifying a non-human vertebrate to express one or more protein(s) that can be activated by light in (a) cell(s) of the hypothalamic-pituitary-adrenal axis, wherein the protein(s) that can be activated by light are capable of inducing the release of (i) corticotrophin-releasing hormone (CRH) and/or arginine-vasopressin (AVP) from neurons in the paraventricular nucleus of the rostral hypothalamus (ii) adrenocorticotropic hormone (ACTH) from corticotroph cells in the anterior pituitary and/or (iii) glucocorticoids from cells in the adrenal cortex. The present invention further relates to an animal model of stress obtained by the method of the invention and the use of said animal model for screening for a compound for preventing, ameliorating or treating stress and/or stress-associated diseases. Further, the present invention also relates to a method of screening for a compound for preventing, ameliorating and/or treating stress and/or stress-associated diseases and methods of analyzing stress behavior in fish.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充