Sultan Darvesh,Eric Joy,Earl Martin,Ian Macdonald,Ian Pottie
申请号：
US13061000
公开号：
US08795630B2
申请日:
2009.08.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimers Disease and related dementias especially compounds of Formula (I) wherein R1 is selected from the group consisting of hydrogen, cyano, fluoro, iodo, alkyl, and aryl R2 is selected from the group consisting of hydrogen, alkyl, and aryl X is selected from the group consisting of CH2, CH2O, oxygen, OCH2, CH2S, SCH2, NH, N-alkyl, and N-aryl Y is an optional spacer group, absent or selected from the group consisting of oxygen, sulfur, NH, N-alkyl, and N-aryl and Z is selected from the group consisting of alkyl substituted with cyano, fluoro, or iodo and aryl substituted with cyano, fluoro, or iodo. In a preferred embodiment, R1 and R2 are hydrogen, X is CH2O, Y is absent, and Z is phenyl substituted with fluoro, cyano, or iodo. In some embodiments, Z is more specifically 18F-phenyl or 123I-phenyl or 131I-phenyl. Other compounds are also provided.
