Edward T. Kisak,John M. Newsam,Dominic King-Smith,Pankaj Karande,Samir Mitragotri
申请号：
US12848792
公开号：
US08343962B2
申请日:
2010.08.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
It has been discovered that certain combinations compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) at least one active agent (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.
