Tao Yu,Himatkumar Patel,Kannie M.Y. Chan,Nikita Oskolkov,Michael McMahon,Justin Hanes
申请号：
US14765881
公开号：
US20160206760A1
申请日:
2014.02.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.
