ARNE SKERRA,MARTIN SCHLAPSCHY,TECHNISCHE UNIVERSITÄT MÜNCHEN,ULI BINDER
申请号：
BR112012029577
公开号：
BR112012029577A2
申请日:
2011.05.20
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
biosynthetic proline / alanine random helical polypeptides and their uses - the present invention relates to a biosynthetic random helical polypeptide or biosynthetic conjugated random helical polypeptide or segment, wherein said biosynthetic helical biosynthetic random helical polyeotide, said biosynthetic helical polypeptide or said biosynthetic conjugate comprises an amino acid sequence consisting only of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least approximately 50 proline (pro) and alanine (ala) amino acid residues. at least approximately said 50 proline (pro) and alanine (ala) amino acid residues may be constituent (s) of a heterologous polypeptide or a heterologous polypeptide construct. Also the uses and methods of use of these biosynthetic random helical polypeptides or polypeptide segments or said conjugates are described. The uses may, inter alia, comprise medical uses, diagnostic uses or uses in the food industry as well as other industrial applications such as the paper industry, oil recovery, etc. in particular, a drug conjugate is provided comprising (i) a random helical polypeptide or polypeptide segment comprising an amino acid sequence consisting only of proline and alanine amino acid residues, wherein said amino acid sequence consists of at least 50 amino acid residues. proline (pro) and alanine (ala) amino acids, and (ii) a drug selected from consisting of (a) a biologically active protein or polypeptide that comprises or is an amino acid sequence that has or mediates a biological activity and ( b) a small drug molecule. furthermore, nucleic acid molecules encoding the biosynthetic random helical polypeptide or polypeptide segment and / or heterologous biologically active proteins as well as vectors and cells comprising said nucleic acid molecules are described. furthermore, the present invention provides compositions comprising the compounds of the invention as well as specific uses of the random
