Preparation of benzofurans and use thereof as synthetic intermediates

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专利权人:

MAPI PHARMA LIMITED

发明人:

Marom, Ehud,Mizhiritskii, Michael,Rubnov, Shai

申请号：

AU2011213921

公开号：

AU2011213921A1

申请日:

2011.02.10

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention.

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