ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
发明人:
LA MONICA, NICOLA,FACCIABENE, ANDREA,AURISICCHIO, LUIGI,CILIBERTO, GENNARO
申请号：
CA2555013
公开号：
CA2555013C
申请日:
2005.02.03
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Polynucleotides encoding carcinoembryonic antigen (CEA) fusion proteins areprovided, the CEA fusion proteins comprising a CEA protein, or functionalvariant thereof, fused to a substantial portion of an immunoenhancing element.The polynucleotides of the present invention can elicit an immune response ina mammal, which, in preferred embodiments, is stronger than the immuneresponse elicited by a wild-type CEA. The gene encoding CEA is commonlyassociated with the development of human carcinomas. The present inventionprovides compositions and methods to elicit or enhance immunity to the proteinproduct expressed by the CEA tumor-associated antigen, wherein aberrant CEAexpression is associated with a carcinoma or its development. This inventionspecifically provides adenoviral vector and plasmid constructs carryingpolynucleotides encoding CEA fusion proteins and discloses their use invaccines and pharmaceutical compositions for preventing and treating cancer.
